Basic Information
VIS ID
TVIS44025165
Fusion event
HTLV-1-LEF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
108987692/108066536 (Hg38)
End
108987692/108066536 (Hg38)
Orient
+
Location type
Intronic
Target gene
LEF1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-34a-5p ; hsa-mir-218-5p ; hsa-mir-449a ; hsa-mir-34c-3p ; hsa-mir-452-5p
Nearest miRNA
hsa-mir-12113/Upstream/6736122; hsa-mir-1243/Downstream/1422162;
Nearest TSS
ENST00000502981/Upstream/38917; ENST00000503574/Downstream/4359;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/76322, chr4-CpG: 223/Downstream/100055
Nearest cancer related gene
LEF1(OG, No orient, 0)
Upstream sequence
CCTATGACCCTGAGCTCACTGCATGACTGAATGCCTCACAGGTGCTATAATGGGCTCTGTCCCCAGAGCACCACCTGGGTCTCAGCACCACGCTCCCCCA
Downstream sequence
CTCACACATGTCTAGAACATAGCCAGCACACAGTGACCAACTGAGCCTGCACCGTTACGCTTCTACCGCTAAATCAAATAACCTGTTACCTTCTAGGATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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