Basic Information
VIS ID
TVIS44025173
Fusion event
HTLV-1-UGT8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
115604272/114683116 (Hg38)
End
115604272/114683116 (Hg38)
Orient
+
Location type
Intronic
Target gene
UGT8
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-148b-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-1260b ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3658 ; hsa-mir-4477a ; hsa-mir-3653-3p ; hsa-mir-126-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-324-5p ; hsa-mir-20a-3p ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-4497 ; hsa-mir-4454 ; hsa-mir-3151-3p ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-1227-3p ; hsa-mir-3117-3p ; hsa-mir-1197
Nearest miRNA
hsa-mir-12113/Upstream/26262; hsa-mir-1305/Downstream/10824143;
Nearest TSS
ENST00000502981/Upstream/60749; ENST00000604093/Downstream/430661;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/83340, chr4-CpG: 21/Downstream/1916159
Nearby gene
UGT8(+6070) ;
Upstream sequence
ctgcactccagcctgggcaacagagtaagactccgtctcaaaaaaaaaaaaaaGTTTAACAGTATTAAGAGTGTCATCCTAAAATCCTATTATCAAGTAC
Downstream sequence
AAAAGGAGACTAAATAATGTGCCTTTCCATAGCCTGCAAATAAATAACCCATTTATTCGTGCAATTAAGCAATGATTGTCAGTTTTTAAAACTCTAATTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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