Basic Information
VIS ID
TVIS44025203
Fusion event
HTLV-1-TBC1D9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
141638945/140717791 (Hg38)
End
141638945/140717791 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4C
Target gene
TBC1D9
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-9-5p ; hsa-mir-132-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-27b-3p ; hsa-mir-381-3p ; hsa-mir-495-3p ; hsa-mir-27a-3p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-12113/Upstream/15210484; hsa-mir-1305/Downstream/2625669;
Nearest TSS
ENST00000502981/Upstream/5623; ENST00000609937/Downstream/38329;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/148567, chr4-CpG: 108/Downstream/37975
Upstream sequence
GAAACAGATTCTTTCTACAGCTCAGGTGCAGCGTGAAGATTATGTGATTGGGACAAGTATGTGTTTCATGTTCTCAGGGTTCCCACTGGGTAGAACACAG
Downstream sequence
TGCAGTCATGAAAGACAGACTGGAAAGCCATGGTATCCCCAGGAGCCCCCCAACTTATTTCTTTAAGTCTACAGGTCACAACTTCCCAGTGGTACCCCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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