Basic Information
VIS ID
TVIS44025248
Fusion event
HTLV-1-LDB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
16747173/16745550 (Hg38)
End
16747173/16745550 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LDB2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-7154-3p ; hsa-mir-4515 ; hsa-mir-3169
Nearest miRNA
hsa-mir-12113/Upstream/3117593; hsa-mir-12115/Downstream/3782725;
Nearest TSS
ENST00000502981/Upstream/19048; ENST00000511148/Downstream/13825;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/384407, chr4-CpG: 79/Downstream/766136
Upstream sequence
AATTTATCCAAAGTTTAGCAAATTCACAATGACAAATGTAACAGTTCCTCTAAATTGAAGTTCATCTCCTGGCAGTTTTGGAGGCTTGGAGAAAATGCCA
Downstream sequence
GCAACAAGGACTTGGAAGGAAATAAATCTTTAGATTCCCTGAAAACACAGAGAGTTATTGTGGAAGACATATGGAGGACCCCATACTGCGTTAAGAAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate