Basic Information
VIS ID
TVIS44025275
Fusion event
HTLV-1-SORBS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
186738766/185817612 (Hg38)
End
186738766/185817612 (Hg38)
Orient
+
Location type
Intronic
Target gene
SORBS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1226-3p ; hsa-mir-129-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-3671 ; hsa-mir-139-3p ; hsa-mir-372-5p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-12113/Upstream/879172;
Nearest TSS
ENST00000502981/Upstream/4488; ENST00000456728/Downstream/100528;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/178405, chr4-CpG: 123/Downstream/286966
Upstream sequence
TAGAGTGTAGCTCCCATGACCTTTCCCACTTAGCATTGTGTCCTGTGGCAGCAGTGGCCCCCAGGTACTTCCGGGCAACGTGCCACCCTACCCAGTGCAG
Downstream sequence
AAAAAGCACTGGGCTCTGCCGTCACGGCATTGTTGAATTAGTAACGAAACGCACCAGGCTCAGCAAACAAAACCTGGCAAGAAGGATTTTAAAACAAATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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