VISDB - VIS Detail

Basic Information

VIS ID

TVIS44025281

Fusion event

HTLV-1-SLIT2 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr4

Cytoband

p15.31

Reference genome

GRCh37/hg19

Start

20287250/20285627 (Hg38)

End

20287250/20285627 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA4D

Target gene

SLIT2

miRNAs that regulate target gene

hsa-mir-330-3p ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-12113/Upstream/6657670; hsa-mir-12115/Downstream/242648;

Nearest TSS

ENST00000502981/Upstream/30707; ENST00000509099/Downstream/247772;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/30382, chr4-CpG: 54/Downstream/414567

Nearest cancer related gene

SLIT2(TSG, No orient, 0)

Upstream sequence

ATAGAAACTTTTGCACTTTACTCttttatttttattttttctgagacgatgtcttgctctgttatgcagggagtgcagtggtgtgatctcagctcactgc

Downstream sequence

aacctatgcctcctgattcaagtgatcctccctcctaaacctcccaagtaattggaactacaggcacacatcaccacgcccagctaatttttgtatttct

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.