Basic Information
VIS ID
TVIS44025287
Fusion event
HTLV-1-CCDC149 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
24884594/24882972 (Hg38)
End
24884594/24882972 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
CCDC149
miRNAs that regulate target gene
hsa-mir-488-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4766-5p ; hsa-mir-651-3p ; hsa-mir-3133 ; hsa-mir-548b-3p ; hsa-mir-510-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-494-3p ; hsa-mir-299-3p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-8485 ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6868-3p ; hsa-mir-4635 ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-4796-5p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-600 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-3938 ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-12113/Upstream/362682; hsa-mir-1243/Downstream/3936610;
Nearest TSS
ENST00000502981/Upstream/29704; ENST00000510415/Downstream/29914;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/82692, chr4-CpG: 89/Downstream/29639
Upstream sequence
AAAATCAAACCTTTCTCCAACAGTAATTGCCCAAATAGCTAAGCATTCATTAGATTTCTACTTCCTCACATAGGCCAAGAAAAACTAAAAATGCATTAAA
Downstream sequence
TGCAGTAAATCTTCAAGCTTCCATATGCTTACGTGCCTGTCCCCCCAGCCTCCTAACTTCCTTATCCTTTAGAGTCAGCACTGAATGCTGGAGCTGGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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