Basic Information
VIS ID
TVIS44025299
Fusion event
HTLV-1-PCDH7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
31060331/31058709 (Hg38)
End
31060331/31058709 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
PCDH7
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-192-5p ; hsa-mir-25-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-4261 ; hsa-mir-3688-3p ; hsa-mir-4789-3p ; hsa-mir-8076 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-6720-5p ; hsa-mir-1277-5p ; hsa-mir-6512-3p ; hsa-mir-190a-3p ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-5011-5p
Nearest miRNA
hsa-mir-12113/Upstream/2239041; hsa-mir-1243/Downstream/5367657;
Nearest TSS
ENST00000502981/Upstream/132996; ENST00000515292/Downstream/112435;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/335489, chr4-CpG: 100/Downstream/5185300
Upstream sequence
TTTGACCATTGATTTAATTAAGGAGGTAAAAGACCTTCTTATAATGTAGGTAATATTTTTGGAAATTAATGAATGAAAGTTAATTGCCTGGCAGTCTTTC
Downstream sequence
ACACCAACTGTGTTGGCAATCTAGTGGCAAACCTAATAAACACTCTCTCATGTAGACAAATGTGCTTTAGATAATGATGGAGTTTTTGAGTGGGTGATTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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