Basic Information
VIS ID
TVIS44025316
Fusion event
HTLV-1-LIMCH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
41462993/41460976 (Hg38)
End
41462993/41460976 (Hg38)
Orient
+
Location type
Intronic
Target gene
LIMCH1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-30e-5p ; hsa-mir-3140-3p ; hsa-mir-4462 ; hsa-mir-3148 ; hsa-mir-95-5p ; hsa-mir-888-5p ; hsa-mir-944 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-137 ; hsa-mir-6079 ; hsa-mir-6873-3p ; hsa-mir-452-3p ; hsa-mir-6820-3p ; hsa-mir-4261 ; hsa-mir-3164 ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-676-5p ; hsa-mir-6515-3p ; hsa-mir-1236-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-890
Nearest miRNA
hsa-mir-12113/Upstream/958857; hsa-mir-1243/Downstream/6191693;
Nearest TSS
ENST00000502981/Upstream/42237; ENST00000509454/Downstream/77181;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/99354, chr4-CpG: 32/Downstream/183299
Upstream sequence
TCAGTTCCCCTGACTGTGGCAGGTGCTGCACATTGGCCCATTGGAAATTGCAGTTGTTTTTAATATTTTTTTAAAACAAATGATCTCCGACTGGCTCTGT
Downstream sequence
TGCTCCTAATTTCCTTTATTTGTTGAACACTCAAGATGCAATAATCTGGTTTGTTTATAGTTTTGTGGAAATAGGaataatgaacatttatgtagtggtt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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