Basic Information
VIS ID
TVIS44025330
Fusion event
HTLV-1-RASL11B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
53730578/52864411 (Hg38)
End
53730578/52864411 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
RASL11B
miRNAs that regulate target gene
hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-627-3p ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-589-3p
Nearest miRNA
hsa-mir-12113/Upstream/151664; hsa-mir-1243/Downstream/8058208;
Nearest TSS
ENST00000502981/Upstream/265; ENST00000504048/Downstream/81238;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1578, chr4-CpG: 43/Downstream/501130
Upstream sequence
TGTTGTTTTTTAAAAAAAATCTGAAGTAAGCCCACCAAATAGAAATAAACTATCGCTGTTTTGTGTGCATTTATGCATTGTGCATTTTTTTTCTAGCTTA
Downstream sequence
AAACTCACAATGTTTTAAAAGTTGTACAAGAAGGAAGAACATAATCTCTTTTATTTGCCTTCATAGGTAATCTCTATACTAGACAAGTTCAGATAGAAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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