Basic Information
VIS ID
TVIS44025335
Fusion event
HTLV-1-KDR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
55986454/55120287 (Hg38)
End
55986454/55120287 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
KDR
miRNAs that regulate target gene
hsa-mir-19b-1-5p ; hsa-mir-200b-3p ; hsa-mir-16-5p ; hsa-mir-335-5p ; hsa-mir-1236-3p ; hsa-mir-17-3p ; hsa-mir-200c-3p ; hsa-mir-15b-5p ; hsa-mir-4799-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-296-5p ; hsa-mir-199a-3p ; hsa-mir-195-5p
Nearest miRNA
hsa-mir-12113/Upstream/2407540; hsa-mir-1243/Downstream/5802332;
Nearest TSS
ENST00000502981/Upstream/23567; ENST00000514398/Downstream/2634;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/461157, chr4-CpG: 64/Downstream/4948
Upstream sequence
GTCATTCGGTTTAATGCTTAGTATTCAACAAGTATGAAGCAATGGCAATAACCTACCCAAGGTCCTTTGTGGACCCCCAGCACTCTTCCAGGAGGGTAAC
Downstream sequence
ATCACCTCCACTTGTCACAGTCTCTACCAAAAACACACAGGTCCTAAGAAGGCTCCATGCCTTTCGTGTGTGATCACTATGTTAAACCCAAGGGTCTTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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