Basic Information
VIS ID
TVIS44025353
Fusion event
HTLV-1-PDE6B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
645943/652154 (Hg38)
End
645943/652154 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDE6B
miRNAs that regulate target gene
hsa-mir-6821-5p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-585-3p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4486 ; hsa-mir-873-5p ; hsa-mir-383-3p ; hsa-mir-6765-5p ; hsa-mir-7160-5p ; hsa-mir-3656 ; hsa-mir-6087 ; hsa-mir-3197 ; hsa-mir-7162-3p ; hsa-mir-4649-3p ; hsa-mir-544b ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p
Nearest miRNA
hsa-mir-571/Upstream/301902; hsa-mir-12113/Downstream/1334230;
Nearest TSS
ENST00000502981/Upstream/169; ENST00000488061/Downstream/119;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/364, chr4-CpG: 21/Downstream/1250
Upstream sequence
AGGGTCCACACCCATCGGTGAGGCAGGAGTCAGGGTAGGCTGCAGACCCGGGCGGAGATTGCGAGGCAGGGGTCAGGGTCACTGGAGAAACATGGCTCAG
Downstream sequence
GAAAGGCTTCAGGGAGAAAAAGGTGTTGGACGAGAGAGGCTGGTGCTCAGGGGCTGCAGGGGGGCCGGGCCTCAGCAGGGAGGGAGGGAGGGACTCTGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate