Basic Information
VIS ID
TVIS44025355
Fusion event
HTLV-1-EPHA5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
66362660/65496942 (Hg38)
End
66362660/65496942 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPHA5
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-181a-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p
Nearest miRNA
hsa-mir-12113/Upstream/4574258; hsa-mir-1243/Downstream/779882;
Nearest TSS
ENST00000502981/Upstream/472457; ENST00000509473/Downstream/172993;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2147076, chr4-CpG: 32/Downstream/172533
Upstream sequence
AATGAATGGATTGGCATGAATATTATAACAACTATTTAGAATCACATAAAGAAAGTGTTTTCTGATATTTCTATGAGCATTTCTAAGCTTATCATCAGGT
Downstream sequence
AAATGCGCATGAAGTAAATCTTTTTATTCTGTGGATTTTCTACATGTTCATATTATTCTTATTTCTCACTGGCTAATAAAGCCAAACTTTAATATGCTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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