Basic Information
VIS ID
TVIS44025434
Fusion event
HTLV-1-VDAC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
133349578/134013887 (Hg38)
End
133349578/134013887 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
VDAC1
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-320c ; hsa-mir-877-5p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-10a-5p ; hsa-mir-197-3p ; hsa-mir-106a-5p ; hsa-mir-29a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/586181; hsa-mir-103a-1/Downstream/211870;
Nearest TSS
ENST00000502646/Upstream/8740; ENST00000521970/Downstream/100824;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/8069, chr5-CpG: 30/Downstream/57229
Nearby gene
VDAC1(-8754) ;
Upstream sequence
aaaaattagccaggcatggttgcgggcacctgtaatcccagctactcgggaggctgaggcaggagaatcacttgaatccgggaggcggaggttgcagtga
Downstream sequence
gctgagatcgtgccactgcactccagcctgggtgacagagtgagactccgtctcccatcccaccccccgaaaaaaagtgggcagaggacatgaacaggca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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