Basic Information
VIS ID
TVIS44025446
Fusion event
HTLV-1-NRG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
139277712/139898127 (Hg38)
End
139277712/139898127 (Hg38)
Orient
+
Location type
Intronic
Target gene
NRG2
miRNAs that regulate target gene
hsa-mir-5089-5p ; hsa-mir-377-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-8485 ; hsa-mir-136-5p ; hsa-mir-4297 ; hsa-mir-4724-5p ; hsa-mir-515-5p ; hsa-mir-519e-5p ; hsa-mir-5581-5p ; hsa-mir-6516-3p ; hsa-mir-96-3p ; hsa-mir-2861 ; hsa-mir-5001-3p ; hsa-mir-7851-3p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-10397/Upstream/2250478; hsa-mir-103a-1/Downstream/665544;
Nearest TSS
ENST00000502646/Upstream/26324; ENST00000502351/Downstream/6183;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/49425, chr5-CpG: 107/Downstream/5638
Upstream sequence
GTTCGTTCAAGAATGGATTGAGCACTGAGCACATTTCGAGTGCTGAGGGTCAAGTTGATGTGGCCTTCGCCCTGGTGGAGATTCTGGCTGAGCAATGTGC
Downstream sequence
Tcctcaccttggggaccagggaggccctgtggaggaaacaaagcctatgctggacctgaaggatgagcaagagtttgctaagagagaacatgtgccaggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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