Basic Information
VIS ID
TVIS44025447
Fusion event
HTLV-1-PCDHB11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
140580445/141200872 (Hg38)
End
140580445/141200872 (Hg38)
Orient
-
Location type
Exonic
Target gene
PCDHB11
miRNAs that regulate target gene
hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-1273e ; hsa-mir-1286 ; hsa-mir-4722-5p ; hsa-mir-873-5p ; hsa-mir-6087 ; hsa-mir-219b-3p ; hsa-mir-4740-3p ; hsa-mir-4768-3p ; hsa-mir-302f ; hsa-mir-665 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-8055 ; hsa-mir-548s ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-1290 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10397/Upstream/552946; hsa-mir-103a-1/Downstream/2478988;
Nearest TSS
ENST00000502646/Upstream/1262; ENST00000624949/Downstream/524;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/6129, chr5-CpG: 86/Downstream/278
Upstream sequence
CATAATTCACGTGATAGATGTAAATGACAATGCTCCTGAAATCACTGTGTCATCAATTACCAGTCCAATCCCAGAAAATACGCCAGAGACCGTGGTTATG
Downstream sequence
GTTTTTAGTATCCAAGATATAGACTCTGGGGACAACGGAAGAATTGTTTGTTCCATTCCGGAAGACCTCCCATTCGTGCTAAAATCTTCAGTTGAGAATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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