Basic Information
VIS ID
TVIS44025456
Fusion event
HTLV-1-PDGFRB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
149495641/150116078 (Hg38)
End
149495641/150116078 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDGFRB
miRNAs that regulate target gene
hsa-mir-224-5p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-30b-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-767-5p ; hsa-mir-9-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-10397/Upstream/383188; hsa-mir-103a-1/Downstream/1406009;
Nearest TSS
ENST00000502646/Upstream/1120; ENST00000231656/Downstream/6124;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/114839, chr5-CpG: 20/Downstream/16659
Nearest cancer related gene
PDGFRB(OG, No orient, 0)
Upstream sequence
GAAGGAGCCCAGGAGGATTCCAGCAGcagtcatgaagagccttcggtgtgtccacccctgcaccgtaggcttcacacactccggctcatttaactcttgt
Downstream sequence
gaaaactatgcaaggcctgcaccgtgaggaaagtgtggctcagagaggttatatcactgccccacttcacacagcagggaagtgcaggagctggaacttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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