Basic Information
VIS ID
TVIS44025492
Fusion event
HTLV-1-NPM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
170832929/171405925 (Hg38)
End
170832929/171405925 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
NPM1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-93-3p ; hsa-mir-421 ; hsa-mir-625-5p ; hsa-mir-598-3p ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-23b-3p ; hsa-mir-15b-5p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-646 ; hsa-mir-4428 ; hsa-mir-4521 ; hsa-mir-6888-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4484 ; hsa-mir-8053 ; hsa-mir-3121-3p ; hsa-mir-4450 ; hsa-mir-4461 ; hsa-mir-5186 ; hsa-mir-2115-3p ; hsa-mir-8087 ; hsa-mir-5197-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-4468 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-586 ; hsa-mir-134-5p ; hsa-mir-144-3p ; hsa-mir-16-1-3p ; hsa-mir-182-5p ; hsa-mir-3118 ; hsa-mir-31-5p ; hsa-mir-3164 ; hsa-mir-3529-3p ; hsa-mir-4696 ; hsa-mir-4709-5p ; hsa-mir-6809-5p ; hsa-mir-6820-3p
Nearest miRNA
hsa-mir-10397/Upstream/19165; hsa-mir-10523/Downstream/1256240;
Nearest TSS
ENST00000502646/Upstream/5139; ENST00000524204/Downstream/1568;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/17274, chr5-CpG: 208/Downstream/12831
Nearest cancer related gene
NPM1(TSG, No orient, 0)
Upstream sequence
ACCCTAGTCAGAAGTGATTTTCAGCAGATTGAGACATTTCTCTTTGCCCTTTACACCAAGTTGTCACCAGTTAATACATGTAGTAATAGCTAGATTTCGT
Downstream sequence
GAATGACTAATAGGCTTAAATCTAGTTTCCTTTTGTCTTAAATAATGGAAATGTGGGAAGAGGGTTAGGTCTCTCATCTGCTTGACTGGGGGATTTGAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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