Basic Information
VIS ID
TVIS44025506
Fusion event
HTLV-1-COL23A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
177681020/178254019 (Hg38)
End
177681020/178254019 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
COL23A1
miRNAs that regulate target gene
hsa-mir-676-5p ; hsa-mir-4474-5p ; hsa-mir-8086 ; hsa-mir-4680-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4714-3p ; hsa-mir-7151-3p ; hsa-mir-767-5p ; hsa-mir-5095 ; hsa-mir-4735-5p ; hsa-mir-1224-3p ; hsa-mir-6504-3p ; hsa-mir-501-3p ; hsa-mir-502-3p ; hsa-mir-4438 ; hsa-mir-32-3p
Nearest miRNA
hsa-mir-10397/Upstream/1624519; hsa-mir-1229/Downstream/1544259;
Nearest TSS
ENST00000502646/Upstream/21228; ENST00000521803/Downstream/11815;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/21093, chr5-CpG: 23/Downstream/48203
Upstream sequence
ttgggaggctgaggtggcaggatcacttgaggtcaggagtttgagaccagcccggccaacatggtgaaaccccgtctctactaaaaatataaaaattagc
Downstream sequence
caggtgtggtggcgcatgcctgtagtcccagctacttgggaggctgaggcaggagaattgcttgaacctgggaggaggaggttgcagtgagccgagatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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