Basic Information
VIS ID
TVIS44025526
Fusion event
HTLV-1-PDZD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
31945760/31945654 (Hg38)
End
31945760/31945654 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
PDZD2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6501-3p ; hsa-mir-574-3p ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-4448 ; hsa-mir-4756-3p ; hsa-mir-3919
Nearest miRNA
hsa-mir-10397/Upstream/9495; hsa-mir-103a-1/Downstream/448724;
Nearest TSS
ENST00000502646/Upstream/9502; ENST00000509256/Downstream/106840;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/90334, chr5-CpG: 124/Downstream/227838
Upstream sequence
GGGCTGAACCACACCAAAATTCTGTCTTTGGGTTTGGCTTTACTAGATTCCCTTGAGAAACTCTCCCTCAACCCTGTTTTTCCCCCTTGTTCTCTTCCCT
Downstream sequence
ATGGGAACCCCCTAGGGTGTTCTGCCGCAGCTTTCATAGTTTCAGACTCTACCTGCCTGAGACCACATCGTCTTCCCTGGCTTGGATCCAGGTGCTTCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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