Basic Information
VIS ID
TVIS44025545
Fusion event
HTLV-1-PLCXD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41456409/41456307 (Hg38)
End
41456409/41456307 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
PLCXD3
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6749-3p ; hsa-mir-4691-5p ; hsa-mir-6792-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-627-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-302f ; hsa-mir-6868-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-642a-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4469 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-1470 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-5088-3p ; hsa-mir-6756-3p ; hsa-mir-6875-3p ; hsa-mir-4778-3p ; hsa-mir-4743-3p ; hsa-mir-6888-3p ; hsa-mir-3182 ; hsa-mir-3120-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-4327 ; hsa-mir-100-3p ; hsa-mir-34c-3p
Nearest miRNA
hsa-mir-10397/Upstream/2898746; hsa-mir-103a-1/Downstream/12495197;
Nearest TSS
ENST00000502646/Upstream/194869; ENST00000505931/Downstream/54294;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/620536, chr5-CpG: 26/Downstream/53374
Upstream sequence
gatagataacggaagTTGTTTATTACCCTCAAGAATTCTGGAACTCTCCTGGCATCTTGGATTCTGACTAGTTCTGTGGAAATTATCTGAATCCTGTTTG
Downstream sequence
TAATCTTTGTACAATCACTTAGCAAATAAAAACATAAATATCCATCATACTTCTTTAAAACCTATTGTTACAAAACATTCTGTGTTCTGCTAAGTATAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate