Basic Information
VIS ID
TVIS44025562
Fusion event
HTLV-1-ARL15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
53604030/54308200 (Hg38)
End
53604030/54308200 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
ARL15
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-7-5p ; hsa-mir-222-5p ; hsa-mir-3177-5p ; hsa-mir-7110-3p ; hsa-mir-4797-3p ; hsa-mir-4264 ; hsa-mir-936 ; hsa-mir-648 ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-3129-5p ; hsa-mir-6873-3p ; hsa-mir-6817-3p
Nearest miRNA
hsa-mir-10397/Upstream/356601; hsa-mir-103a-1/Downstream/862332;
Nearest TSS
ENST00000502646/Upstream/427149; ENST00000512618/Downstream/2215;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/747160, chr5-CpG: 59/Downstream/1902
Upstream sequence
GAAAAATAATGTGTGGCACATCATTTTCTCTGAAAGTCGACAAGCAAAAGGTGAACACAAAAAGGCTACCTCGGGAGGGCTAGTTTTTTGTTTTGAGATG
Downstream sequence
GTTTTTCTGTTTGTTTCCATCCAGTTTAATGCTAAAGAATTTTCTGAAATCTTTTCACAGGGGACACTTGGCACACTCACAAAAACTAAACTGTTTCCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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