Basic Information
VIS ID
TVIS44025573
Fusion event
HTLV-1-DEPDC1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59924338/60628511 (Hg38)
End
59924338/60628511 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
DEPDC1B
miRNAs that regulate target gene
hsa-mir-361-5p ; hsa-mir-4282 ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-95-5p ; hsa-mir-455-5p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10397/Upstream/924808; hsa-mir-103a-1/Downstream/11540956;
Nearest TSS
ENST00000502646/Upstream/106391; ENST00000457499/Downstream/180;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/734830, chr5-CpG: 87/Downstream/71036
Upstream sequence
Tgaaaggccaatgggaccattgtttgttcagccagagaagaaactcagaagagttaattgtagtttttgaccaacaaaaggaattaaaaaaaaagtcaca
Downstream sequence
gtttcattttcactaagaacaggtataaaaaataaaaggtttatacttagccaggattcagactacacatCAATTAGTAAAAATTCTTGCCTAAAGAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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