Basic Information
VIS ID
TVIS44025594
Fusion event
HTLV-1-IQGAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
75784884/76489059 (Hg38)
End
75784884/76489059 (Hg38)
Orient
-
Location type
Intronic
Target gene
IQGAP2
miRNAs that regulate target gene
hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-549a ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-548e-5p ; hsa-mir-92a-1-5p
Nearest miRNA
hsa-mir-10397/Upstream/3610396; hsa-mir-103a-1/Downstream/6351096;
Nearest TSS
ENST00000502646/Upstream/84635; ENST00000504815/Downstream/58350;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/84724, chr5-CpG: 111/Downstream/226236
Nearest cancer related gene
IQGAP2(TSG, No orient, 0)
Upstream sequence
gtgttgttcctcccttcaggtaggaggttcagtaatcattcagggtcacacgactggaaaaggctgaccccagatgtaaagccaggctcccagctccttg
Downstream sequence
ttcttccactgtgttctaAACTCCTTCCCAGCTTGCGCTTGACACAGCCTTGTCTTCTCTCCCTCCGTGCCTCGCAGTGGTAGGGTTCCATGGAACACGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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