Basic Information
VIS ID
TVIS44025600
Fusion event
HTLV-1-HAPLN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
82983322/83687503 (Hg38)
End
82983322/83687503 (Hg38)
Orient
-
Location type
Intronic
Target gene
HAPLN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-4668-5p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-4717-3p ; hsa-mir-130a-5p ; hsa-mir-23b-3p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-129-5p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-5587-5p ; hsa-mir-6801-5p
Nearest miRNA
hsa-mir-10397/Upstream/847279; hsa-mir-103a-1/Downstream/3427376;
Nearest TSS
ENST00000502646/Upstream/4965; ENST00000507060/Downstream/33310;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/212723, chr5-CpG: 59/Downstream/34572
Upstream sequence
GCATAAACAATATAAATAGCTACTTGCTGGCATCATGTTCAAAACATTCATTCAACAATGTTTTAGGAGCAAGTACATAAAATGGAATCTGTGTCCCTGA
Downstream sequence
ATATCTCTCACCATTATAGCATCTAAACAAGGAATGACCTCTTTAAATCTGAATCTCAGCATTTGGTGTCACACTAATGTGATGAGATACTCAACTTTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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