Basic Information
VIS ID
TVIS44025620
Fusion event
HTLV-1-CRYBG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
107017578/106569703 (Hg38)
End
107017578/106569703 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA6F
Target gene
CRYBG1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-21-5p ; hsa-mir-25-3p ; hsa-mir-502-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-145-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-10398/Upstream/7445007; hsa-mir-1202/Downstream/214422;
Nearest TSS
ENST00000381078/Upstream/25119; ENST00000467262/Downstream/2708;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/56593, chr6-CpG: 236/Downstream/403637
Upstream sequence
GCTACTGGAACACTATTATGACCTAATTTATGAGCCATCCTTACTCATCTACAAGTGCTGAAGCAATGTTACATACTTTTTTGCTAAACTCAGATTTTTT
Downstream sequence
AGCCTAATTTCTTGTCCTCCTATCCACCTGCATCCACACATGGCCTGCATGGGGCTGCCTTCCCTGCAGTGTTCTGCAGCCATGCTTCAGGGTATAGCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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