Basic Information
VIS ID
TVIS44025629
Fusion event
HTLV-1-ROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117736019/117414856 (Hg38)
End
117736019/117414856 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10630636; hsa-mir-1202/Downstream/1654191;
Nearest TSS
ENST00000381078/Upstream/77516; ENST00000533950/Downstream/10999;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/143740, chr6-CpG: 113/Downstream/67478
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
TGGAAAAATGGGAGAATATGATGTCCACCAGAAAAATCTCAGCAGGCTGAGGTAATCTGTGGTGGACCAAGTTAAGAGAGTGAAGGAGTATTTGCAAATG
Downstream sequence
CCAAAGGTAAATAGAACAGGAAATGAAAACCACCAATAGCTCTTGCTAGCAAAGGACAGCAGATTCCTCTGCCCATGCTGGCCACTGCAGCAGCCACACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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