Basic Information
VIS ID
TVIS44025660
Fusion event
HTLV-1-SASH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
148834517/148513381 (Hg38)
End
148834517/148513381 (Hg38)
Orient
-
Location type
Intronic
Target gene
SASH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-93-5p ; hsa-mir-181a-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-3944-5p ; hsa-mir-548q ; hsa-mir-8083 ; hsa-mir-4700-3p ; hsa-mir-4744 ; hsa-mir-4773 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-7156-3p ; hsa-mir-1262 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4325 ; hsa-mir-4504 ; hsa-mir-4701-3p ; hsa-mir-508-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6736-5p ; hsa-mir-6742-3p ; hsa-mir-6776-5p ; hsa-mir-6849-3p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-10398/Upstream/7829498; hsa-mir-1202/Downstream/2589294;
Nearest TSS
ENST00000381078/Upstream/4114; ENST00000635873/Downstream/56;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/170302, chr6-CpG: 44/Downstream/46499
Nearest cancer related gene
SASH1(TSG, No orient, 0)
Upstream sequence
TGGAGAGAAGGTTGTTGTCAGGGCGTGCGACGTGAGCTGGAATTGCTCACCCACTGCACAGGGTGTGCCGAGGCGGCTGCTCCCAGGCATGCCCACGCAC
Downstream sequence
CCGTGTTGCACACTCGTTTAGTCAGAGATCTCTTATGCTGTTTCACATTTTGAACAGATACAACAGAGGAAGCTGCATATTGGATGTTGGAGCTGACTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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