Basic Information
VIS ID
TVIS44025697
Fusion event
HTLV-1-PPP1R18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
30648476/30680699 (Hg38)
End
30648476/30680699 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
PPP1R18
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-3973 ; hsa-mir-4251 ; hsa-mir-429 ; hsa-mir-449b-3p ; hsa-mir-4786-3p ; hsa-mir-4796-3p ; hsa-mir-539-5p ; hsa-mir-548a-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548ay-5p ; hsa-mir-548az-5p ; hsa-mir-548b-5p ; hsa-mir-548bb-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548j-5p ; hsa-mir-548o-5p ; hsa-mir-548t-5p ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-559 ; hsa-mir-671-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p ; hsa-mir-8084
Nearest miRNA
hsa-mir-3143/Upstream/96282; hsa-mir-10398/Downstream/210184;
Nearest TSS
ENST00000381078/Upstream/7662; ENST00000442150/Downstream/4045;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/7623, chr6-CpG: 81/Downstream/5916
Upstream sequence
gggaggatttcttgagcccaggagttcgagaccagcctgggcaatagagtgacactgtctctaaaaaagaaaaaaaaaGAAAACCAGATATGACACCTGG
Downstream sequence
GTCCCCATGGGAAGGTAGAACTCAGGAACTGTATatgttactccttgttggctctgaaccctgcagtgtctccccatctcacttggagcaaaaagtctac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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