Basic Information
VIS ID
TVIS44025711
Fusion event
HTLV-1-SRPK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35810403/35842626 (Hg38)
End
35810403/35842626 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
SRPK1
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-652-3p ; hsa-mir-186-5p ; hsa-mir-99a-5p ; hsa-mir-95-5p ; hsa-mir-3926 ; hsa-mir-3922-5p ; hsa-mir-4753-5p ; hsa-mir-7158-5p ; hsa-mir-6881-5p ; hsa-mir-6890-5p ; hsa-mir-7851-3p ; hsa-mir-619-3p ; hsa-mir-4802-3p ; hsa-mir-942-3p ; hsa-mir-6796-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-548m ; hsa-mir-376a-5p ; hsa-mir-376a-2-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-3973 ; hsa-mir-1252-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-6882-3p ; hsa-mir-139-5p ; hsa-mir-22-3p ; hsa-mir-3156-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1236/Upstream/177837; hsa-mir-10398/Downstream/779810;
Nearest TSS
ENST00000381078/Upstream/3785; ENST00000622903/Downstream/26925;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/55489, chr6-CpG: 82/Downstream/77981
Upstream sequence
GGACTCACCTTCATCTCGAGTGTACTCTTCCCCTGAATGAGGTTCAAACAAATAGTCACCTGTGGCCAGTTCAAAGGCCTAAAAAAAAAAGAGGACAGTA
Downstream sequence
TATGAAAGCACAAAAGAAAAGAAGGCCTTTGGAAAGCTGATTGCTATTTGGCTCAATATGAAGTAACTCTTGTTCCCTTGGGAAAACTTATAGATCATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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