Basic Information
VIS ID
TVIS44025713
Fusion event
HTLV-1-MAPK13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
36109013/36141236 (Hg38)
End
36109013/36141236 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA6H
Target gene
MAPK13
miRNAs that regulate target gene
hsa-mir-3691-5p ; hsa-mir-6887-5p ; hsa-mir-4531 ; hsa-mir-6795-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-5187-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-8082 ; hsa-mir-3134 ; hsa-mir-4534 ; hsa-mir-6798-5p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-4773 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-4735-3p ; hsa-mir-4761-5p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-1236/Upstream/476447; hsa-mir-10398/Downstream/481200;
Nearest TSS
ENST00000381078/Upstream/10367; ENST00000446974/Downstream/55508;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/10392, chr6-CpG: 98/Downstream/55119
Upstream sequence
aatactgtaatggtggatacctattgtgcatttgttaccatctgtaggactggataacacagagtgaaccctcaagtaaactatggacttcagttaataa
Downstream sequence
taatgtatcagtattggttcataaattgtaacaattgtgccacactaatgcaagatgttactcatcaagaaaactgaggagagagaaggggaggaagtag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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