Basic Information
VIS ID
TVIS44025771
Fusion event
HTLV-1-KCNQ5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
73340102/72630374 (Hg38)
End
73340102/72630374 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
KCNQ5
miRNAs that regulate target gene
hsa-mir-190a-5p ; hsa-mir-194-3p ; hsa-mir-574-5p ; hsa-mir-6515-5p ; hsa-mir-6867-5p ; hsa-mir-7847-3p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-5693 ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-543 ; hsa-mir-5096 ; hsa-mir-101-3p ; hsa-mir-139-5p ; hsa-mir-4999-3p ; hsa-mir-144-3p ; hsa-mir-6507-5p ; hsa-mir-4282
Nearest miRNA
hsa-mir-10398/Upstream/1226753; hsa-mir-10524/Downstream/337313;
Nearest TSS
ENST00000381078/Upstream/8202; ENST00000443915/Downstream/373622;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6993, chr6-CpG: 22/Downstream/527487
Upstream sequence
AAGAGATATACACCTTTTACAAACTCAGTCATAGTGGTCATTGTTCTCATTTATTGTACCTGTGAGGTAATTCTAGAATCCCTATTCCTTCTTCAGTCAG
Downstream sequence
TGGCTGGATAATCTAATTATAATGTTATAATCCATCATTTCTCTTTTTGAACAGTCAATTTAGTTTaacatttgcttaacagccattatgtatgccaggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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