Basic Information
VIS ID
TVIS44025775
Fusion event
HTLV-1-MYO6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
76523995/75814278 (Hg38)
End
76523995/75814278 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
MYO6
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-143-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-140-5p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-155-3p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-382-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-1264 ; hsa-mir-3692-3p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-10398/Upstream/385805; hsa-mir-10524/Downstream/2724985;
Nearest TSS
ENST00000381078/Upstream/64946; ENST00000462633/Downstream/3238;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/64728, chr6-CpG: 132/Downstream/1648236
Upstream sequence
ctctggctagggcttctgtaaatgctctgtttgtgatctctccctcccacaagcctgtagattctctcaccataccaccattgctgctgccaaggggtgg
Downstream sequence
ggagagagagggtggtgctgagagttgaagactggttttgctcccctctccagtgcctctttctttgatgtgatgttaaaaccagggactggttttaact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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