Basic Information
VIS ID
TVIS44025824
Fusion event
HTLV-1-GRM8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
126775911/127135857 (Hg38)
End
126775911/127135857 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRM8
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-491-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-10525/Upstream/77673; hsa-mir-10399/Downstream/946004;
Nearest TSS
ENST00000635602/Upstream/17585; ENST00000450061/Downstream/79270;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2205712, chr7-CpG: 237/Downstream/115389
Upstream sequence
AAATTTAAATATGATAAGATAGGTCATTTTCTCCATTTGGTTTGCTCCAAGGAGGTTGTTGATTTCTGGCAAATAGATCTTAACTATTATTATTTCATTA
Downstream sequence
GATAGTAATTTCTAAAAATTGAGAATTATTTTTCCTCTTCAAACCAACTACATCTTGCACAATGCTCTGGATATTGTAGGAGTCCCACAGAAGTTCATCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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