Basic Information
VIS ID
TVIS44025833
Fusion event
HTLV-1-PLXNA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
132208516/132523757 (Hg38)
End
132208516/132523757 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7H
Target gene
PLXNA4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-6787-3p ; hsa-mir-4267 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-1226-3p ; hsa-mir-498 ; hsa-mir-4709-3p ; hsa-mir-6744-5p ; hsa-mir-561-5p ; hsa-mir-5002-3p ; hsa-mir-93-3p ; hsa-mir-6830-5p ; hsa-mir-6873-3p ; hsa-mir-7110-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-1178-3p ; hsa-mir-4666a-5p ; hsa-mir-3166 ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-486-3p ; hsa-mir-6817-3p ; hsa-mir-342-3p ; hsa-mir-6852-5p
Nearest miRNA
hsa-mir-10525/Upstream/1646218; hsa-mir-10399/Downstream/511103;
Nearest TSS
ENST00000635602/Upstream/171423; ENST00000573229/Downstream/52713;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/578020, chr7-CpG: 168/Downstream/51958
Upstream sequence
agagaatggtttttgggtggaagaggagttcactgaggagtgacagcagcctgactcaggtgacagtgtcagaaagcgagactggttgctccagcagggg
Downstream sequence
ttgctggtgatgtggaaacaaggggggcggaagagagggacttagtcacacctccttgatttttggattgaggatctgggtgggtgctggtaccatttaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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