Basic Information
VIS ID
TVIS44025865
Fusion event
HTLV-1-KMT2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152077215/152380130 (Hg38)
End
152077215/152380130 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/946491; hsa-mir-153-2/Downstream/5194206;
Nearest TSS
ENST00000635602/Upstream/67834; ENST00000564834/Downstream/55669;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13135, chr7-CpG: 219/Downstream/55002
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
gagaccagctgggtaacatggtgaaaccccatctctactaaaatataaaaacttagccaggggtggcagcatgtgcctgtagtcccagctacttgggagg
Downstream sequence
ctgaggcaggagaatcacttgaacccaggaggcagaagttgcagtgagctgagatcacaccactacactacttcactccaggatgggcaacagagcgaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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