Basic Information
VIS ID
TVIS44025866
Fusion event
HTLV-1-DPP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
154149252/154452167 (Hg38)
End
154149252/154452167 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
DPP6
miRNAs that regulate target gene
hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-4668-5p ; hsa-mir-3153 ; hsa-mir-513b-3p ; hsa-mir-1276 ; hsa-mir-497-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-511-5p ; hsa-mir-6830-3p
Nearest miRNA
hsa-mir-10399/Upstream/3018528; hsa-mir-153-2/Downstream/3122169;
Nearest TSS
ENST00000635602/Upstream/146725; ENST00000478614/Downstream/341427;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/146971, chr7-CpG: 22/Downstream/298182
Upstream sequence
TACAGAGCAGTGTCACCTCGACAGAGAATGCCTGCCAACAGAGCCAGCATGAATGATCCCGGCTAGGAGCTGAGAACTCCATGCTAAGTGCCAGACAGAA
Downstream sequence
TGTGGAAAGAGAAGATGCCAGTACTTCCCATGAAGCTTAGAGTCCACGTAAAGACAATGCATGTGCAAGGAGAATTCCACAGTAGTGTTATCATTAAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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