Basic Information
VIS ID
TVIS44025885
Fusion event
HTLV-1-PLEKHA8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
30130093/30090477 (Hg38)
End
30130093/30090477 (Hg38)
Orient
-
Location type
UTR3
Target gene
PLEKHA8
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-3678-3p ; hsa-mir-4460 ; hsa-mir-2467-3p ; hsa-mir-5681b ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4778-3p ; hsa-mir-3924 ; hsa-mir-7852-3p ; hsa-mir-3668 ; hsa-mir-1273h-3p ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-182-5p ; hsa-mir-4470 ; hsa-mir-1468-3p ; hsa-mir-212-5p ; hsa-mir-1228-3p ; hsa-mir-6813-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-8078 ; hsa-mir-519d-5p ; hsa-mir-330-3p ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-646 ; hsa-mir-382-5p ; hsa-mir-495-5p
Nearest miRNA
hsa-mir-1183/Upstream/409649; hsa-mir-10399/Downstream/199317;
Nearest TSS
ENST00000635602/Upstream/15362; ENST00000434060/Downstream/44333;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/61801, chr7-CpG: 142/Downstream/44137
Upstream sequence
tcaaatctaatgtcaagttctcttaagcaggtaagaactcagaacataatacctgagtgccttcttaaggaaaccatttgataggaaagatgaaccaaat
Downstream sequence
aactcaatgatggatgagctggtagaaaaaaagctggtggtgaaccaaggtcaaactggaaattatagtcacagtatagatatagattataaatattaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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