Basic Information
VIS ID
TVIS44025976
Fusion event
HTLV-1-GRHL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
102575324/101563096 (Hg38)
End
102575324/101563096 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRHL2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4463 ; hsa-mir-4494 ; hsa-mir-4779 ; hsa-mir-6081 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-759 ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-12123/Upstream/860072; hsa-mir-10400/Downstream/562336;
Nearest TSS
ENST00000518652/Upstream/70338; ENST00000474338/Downstream/69130;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/68894, chr8-CpG: 81/Downstream/560590
Upstream sequence
AGTAATAATATTTGAAaataatgaatatttgatgggtactcactatgtgctgggcatcattctaaggatatataagcctcacaaaagccctatgtggtag
Downstream sequence
gtactattattgtcatctctatattctaaatgaggaaactgagggatagagagcataagtatgctcatggttatttagcagtaagtgggagggataggac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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