Basic Information
VIS ID
TVIS44026001
Fusion event
HTLV-1-MTSS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
125728456/124716215 (Hg38)
End
125728456/124716215 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
MTSS1
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-135a-5p ; hsa-mir-7111-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-33a-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-96-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-12123/Upstream/207639; hsa-mir-10400/Downstream/105763;
Nearest TSS
ENST00000518652/Upstream/42702; ENST00000525292/Downstream/11401;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/176935, chr8-CpG: 161/Downstream/11229
Nearest cancer related gene
MTSS1(TSG, No orient, 0)
Upstream sequence
GAACGCAGTCTAGCAGTAAAGCTGATGTGGAACTGCAGATCCCAAAGCCCCAAGGGCAGCATACTCGAGATATAAAGTGCTGGACAGTGCGGTTCCCAGA
Downstream sequence
GTGAGGCAATGCCTCACCTCGGTCTCAGAGGATAAATGGGAATTTTCTTGGCAAAGAGAAATGAAACAAAGAGGGAGGAAGCGTTCCCTGCAAAAGACAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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