Basic Information
VIS ID
TVIS44026041
Fusion event
HTLV-1-TSNARE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
143437668/142356307 (Hg38)
End
143437668/142356307 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
TSNARE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1295b-3p ; hsa-mir-3612 ; hsa-mir-4443 ; hsa-mir-5008-5p ; hsa-mir-650 ; hsa-mir-7108-3p ; hsa-mir-759 ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-1204/Upstream/179889; hsa-mir-10400/Downstream/1376776;
Nearest TSS
ENST00000518652/Upstream/1544; ENST00000569285/Downstream/46581;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/8444, chr8-CpG: 46/Downstream/33963
Upstream sequence
GCAGGCCTTGTTCTGCCCAGGGCGCACGAAAACACCCGGCCCCACGCAGAGAGGCAGCAGGGAGAGTGGTCCTCAGCCCCTCTCTCCACAGGTCTCAGGC
Downstream sequence
CTCGCATCCCAGGTACCTGCCCAGTCGCCATGGCCTCCCTCCCCTCTCTGCACGCTGCCTGGAATGGGGAGGTGGGCAGGAAGTTAGGTCTCAGTAGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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