Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene144782169144720907144756417144683671144688194144690890144692879144699736144701165144720217144721465144713899144714845144698614144699185144730000144730201144713135144713266144732920
Basic Information
VIS ID
TVIS44026044
Fusion event
HTLV-1-ZNF251 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145958305/144732920 (Hg38)
End
145958305/144732920 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
ZNF251
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1233-5p ; hsa-mir-1298-3p ; hsa-mir-185-5p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3165 ; hsa-mir-4306 ; hsa-mir-452-3p ; hsa-mir-4644 ; hsa-mir-4667-5p ; hsa-mir-4700-5p ; hsa-mir-5192 ; hsa-mir-541-3p ; hsa-mir-6134 ; hsa-mir-637 ; hsa-mir-654-5p ; hsa-mir-6731-5p ; hsa-mir-6751-5p ; hsa-mir-6752-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6778-5p ; hsa-mir-6788-5p ; hsa-mir-6803-5p ; hsa-mir-6835-5p ; hsa-mir-6842-5p ; hsa-mir-6878-5p ; hsa-mir-6880-5p ; hsa-mir-7110-5p ; hsa-mir-7155-5p ; hsa-mir-8071 ; hsa-mir-8085 ; hsa-mir-8089 ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-10400/Upstream/270381; hsa-mir-6850/Downstream/59011;
Nearest TSS
ENST00000518652/Upstream/19021; ENST00000528012/Downstream/22521;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2316, chr8-CpG: 72/Downstream/22227
Upstream sequence
aaaaaaaaaaTACATTGGACAGCCTTAGAACCTATCAGACCTCAAAAAACAAACCACAGTAGGTAACTTAATACTAGCAGCAGTAATAATTTGCTTGTAT
Downstream sequence
GTAATAAATTGTTGATAAAggccaggcggggtggctcacacctgtaatcccagcactttgggaggctgaggcgggtggatcatctgaggtcaggagttcg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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