Basic Information
VIS ID
TVIS44026045
Fusion event
HTLV-1-ZNF7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
146055604/144830219 (Hg38)
End
146055604/144830219 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
ZNF7
miRNAs that regulate target gene
hsa-mir-6728-5p ; hsa-mir-6878-3p ; hsa-mir-5187-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6744-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-212-5p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-10400/Upstream/38228;
Nearest TSS
ENST00000518652/Upstream/1177; ENST00000528017/Downstream/3514;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2312, chr8-CpG: 91/Downstream/22327
Upstream sequence
TTGGTGAGGGGGGGTGCGTCTTAACTTGGGCCTTGCTGGGCCTCTTGCCTGTGACTAAGCCCTCTGCTGCATCACACGCCCGAGAGAGTGCCTGGGCTGG
Downstream sequence
GGGATCAGGAGTGGAACTGACGCGGGCATCGTTGGTTGGCCAGGAGCTTCTTGGGGTGTTGGACCAGGCCTGTCCCCCTCTGTCCCGGCTAGTCtggcaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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