Basic Information
VIS ID
TVIS44026049
Fusion event
HTLV-1-MTUS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
17577014/17719505 (Hg38)
End
17577014/17719505 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTUS1
miRNAs that regulate target gene
hsa-mir-125a-5p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-1296-5p ; hsa-mir-183-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-142-3p ; hsa-mir-4646-3p ; hsa-mir-6885-3p ; hsa-mir-4433b-5p ; hsa-mir-4266 ; hsa-mir-4433a-5p ; hsa-mir-3140-3p ; hsa-mir-3919 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-3154 ; hsa-mir-548n ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-mir-4500 ; hsa-let-7c-5p ; hsa-mir-4458 ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-4650-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-362-5p ; hsa-mir-500b-5p ; hsa-mir-501-5p
Nearest miRNA
hsa-mir-124-1/Upstream/37848; hsa-mir-10400/Downstream/4525461;
Nearest TSS
ENST00000518652/Upstream/2915; ENST00000522768/Downstream/2484;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/142060, chr8-CpG: 128/Downstream/81152
Nearest cancer related gene
MTUS1(TSG, No orient, 0)
Upstream sequence
TTTCAAAAGCAATATCACTCAACTATATAATAACAAGAATGTCTCACATATACCCTAGAAAAACGTGAACAGAGAAAGAACGAGAACAAAGTTAACAGTG
Downstream sequence
GTCTGGATAATATTTCCTTTTTAAATAGTCCATTCAGAAGTGCGTAAGTACTAACATGTTTTGTGATGTGGAGCCTAATGAATCtaccgcctgttcctca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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