Basic Information
VIS ID
TVIS44026068
Fusion event
HTLV-1-WRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
30940372/31082856 (Hg38)
End
30940372/31082856 (Hg38)
Orient
+
Location type
Intronic
Target gene
WRN
miRNAs that regulate target gene
hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-3681-3p ; hsa-mir-4717-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-4748 ; hsa-mir-329-5p ; hsa-mir-4464 ; hsa-mir-3664-5p ; hsa-mir-144-3p ; hsa-mir-224-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-3185 ; hsa-mir-4476 ; hsa-mir-6876-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4709-3p ; hsa-mir-6077 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-5197-3p ; hsa-mir-4311 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-3617-3p ; hsa-mir-216b-5p ; hsa-mir-5089-5p ; hsa-mir-4423-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-500b-3p ; hsa-mir-1295b-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-7847-3p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-3928-3p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-124-1/Upstream/1125508; hsa-mir-10400/Downstream/10188192;
Nearest TSS
ENST00000518652/Upstream/49055; ENST00000520169/Downstream/4788;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/49147, chr8-CpG: 142/Downstream/556153
Upstream sequence
cggctaatttttgtatttttagtagagaAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTTGGATTTCGTGATTTGACTGACATCTTTTACA
Downstream sequence
CCAATTATTGCCATTTTTTTATTGGGTACTAATTATTAGTATTGCTTTCTTTATTCGTTAAATAAGAAGTAAAAGAACTTTTAAAAAATAAAATAACTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate