Basic Information
VIS ID
TVIS44026080
Fusion event
HTLV-1-DDHD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
38116400/38258882 (Hg38)
End
38116400/38258882 (Hg38)
Orient
+
Location type
Intronic
Target gene
DDHD2
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-99b-5p ; hsa-mir-10b-5p ; hsa-mir-503-5p ; hsa-mir-1277-5p ; hsa-mir-3646 ; hsa-mir-5692c ; hsa-mir-5692a ; hsa-mir-5692b ; hsa-mir-4460 ; hsa-mir-587 ; hsa-mir-4727-3p ; hsa-mir-4738-3p ; hsa-mir-4766-5p ; hsa-mir-1-5p ; hsa-mir-3677-5p ; hsa-mir-3200-5p ; hsa-mir-6831-3p
Nearest miRNA
hsa-mir-124-1/Upstream/8301534; hsa-mir-10400/Downstream/3012166;
Nearest TSS
ENST00000518652/Upstream/5321; ENST00000526071/Downstream/1179;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/26444, chr8-CpG: 93/Downstream/9697
Nearest cancer related gene
DDHD2(OG, No orient, 0)
Upstream sequence
atccgtaatttcattagattctcaaaaggatgcatgactcaataaatgttgaaccacAGatctagaagaataatagaggcttatatccttaaggcagtcc
Downstream sequence
ctcatgagtgttaatctttttaaatcaaattttgttatgaagtgtggataTAAGTAATTGCTTGTGCATACGTAGAATAATATCTGGAAAACGCATGAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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