Basic Information
VIS ID
TVIS44026157
Fusion event
HTLV-1-NIPAL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99297635/98285407 (Hg38)
End
99297635/98285407 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
NIPAL2
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-335-3p ; hsa-mir-3686 ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-152-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-4742-3p
Nearest miRNA
hsa-mir-12123/Upstream/3212411; hsa-mir-10400/Downstream/108238;
Nearest TSS
ENST00000518652/Upstream/31339; ENST00000521839/Downstream/8703;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/167780, chr8-CpG: 98/Downstream/8268
Upstream sequence
TTGTTTACAGGACTCCTATTTCAGGTGGGTGTCCAGTCCTTCTCAAGGGTGCCCATGTGCTTTGGGAACACTAAGCCTGGTAACTCCAGCCTTGGCGACT
Downstream sequence
GGTATGAGACAGGACATGGTCTTAACATCATCCAATCAGACTAAAGCCCATGTTTTTTCACTAGTGGTTGAGAAAGTCAAGCTCTTTCTTCCAGGGGGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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