Basic Information
VIS ID
TVIS44026172
Fusion event
HTLV-1-ZNF483 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
114287726/111525446 (Hg38)
End
114287726/111525446 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
ZNF483
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-mir-544a ; hsa-mir-541-5p ; hsa-mir-7156-3p ; hsa-mir-1184 ; hsa-mir-4469 ; hsa-mir-4655-3p ; hsa-mir-6803-3p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418
Nearest miRNA
hsa-let-7a-1/Upstream/254232; hsa-mir-12126/Downstream/406654;
Nearest TSS
ENST00000422679/Upstream/213; ENST00000450154/Downstream/48746;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/40942, chr9-CpG: 84/Downstream/105620
Upstream sequence
GGAGCAGCCTACCAACGGGCTGTGCGCTGCGCTGCTGCTGCTTCTGTGGGAGGTGCGCACTCCGCTGCGGGATGGGGCTGTTGGCTTCCCTCCATCCCTC
Downstream sequence
CCTGCGCCacttgggcactgttgacattttgggcgggataatgccttgttttgtttgtggtgtggcggtgagggggaggctctcccgttgtggcaggatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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