Basic Information
VIS ID
TVIS44026194
Fusion event
HTLV-1-TYRP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p23
Reference genome
GRCh37/hg19
Start
12694981/12694981 (Hg38)
End
12694981/12694981 (Hg38)
Orient
+
Location type
Intronic
Target gene
TYRP1
miRNAs that regulate target gene
hsa-mir-599 ; hsa-mir-2054 ; hsa-mir-7975 ; hsa-mir-3161 ; hsa-mir-889-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-4280 ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-499a-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-3163 ; hsa-mir-1183 ; hsa-mir-8087 ; hsa-mir-4432 ; hsa-mir-4668-3p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-4753-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-155-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-382-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6687077; hsa-let-7a-1/Downstream/5878325;
Nearest TSS
ENST00000422679/Upstream/1546; ENST00000470909/Downstream/739;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1076393, chr9-CpG: 28/Downstream/80506
Nearest cancer related gene
TYRP1(OG, No orient, 0)
Upstream sequence
ATTAAATAACAAAGCACTAAACAGTAACAGCCAACAATATTTGATTGTGTTCTATGTGCGAGATAGTAGACTAAGGGTTTAaatgaacatgtattgagtc
Downstream sequence
cttactatgagttaggccttgggctaattgctttttatgtgtgtggtctttgaactttcaattctgtaaagcaagtattatttttatccacattttaatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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