Basic Information
VIS ID
TVIS44026225
Fusion event
HTLV-1-FOCAD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
20851041/20851042 (Hg38)
End
20851041/20851042 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
FOCAD
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-6083 ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-190a-3p ; hsa-mir-487a-3p ; hsa-mir-154-3p ; hsa-mir-3074-3p ; hsa-mir-5011-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-1277-5p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-101-2/Upstream/134854; hsa-let-7a-1/Downstream/661073;
Nearest TSS
ENST00000422679/Upstream/28049; ENST00000604828/Downstream/21765;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/166405, chr9-CpG: 34/Downstream/180397
Upstream sequence
aagtatgttttagcaactgacctcctcctgcaaagcgtccagcttagtacctggtacatagcagttgctcagttcacatttcttgaactgaaCAATAAAG
Downstream sequence
AAGATAAATAATTAGTCTTATGAAAATATTAGATAACCTTAAGTTGGTTTAAGTGTCAGGGTTTGTCTTGTCTATCTCTAGTGAAAACTTATTCCTTTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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